Endocrine Abstracts

Although subclinical Cushing’s syndrome (SCS) is an important metabolic risk factor in patients with adrenal incidentaloma, the diagnostic criteria for SCS has not been established yet. The aim of this study was to evaluate the diagnostic measures of SCS and to investigate the availability of insülin hypoglycemia test (IHT) in the diagnosis of SCS. Twenty patients with adrenal incidentaloma CT characteristics highly suggestive of benign adrenal adenoma with no overt ...

The relationship between increased risk of cardiovascular disease (CVD) and atherosclerosis in subclinical hypothyroidism (sHT) have been demonstrated in several studies. This relation was attributed to dyslipidemia which is common in sHT. Apo A1, apo B100, Lp (a), hsC-reactive protein (hsCRP), fibrinogen and total homocysteinemia (tHcy) are the main non-traditional cardiovascular risk factors. In addition, paraoxon 1 (PON 1) activity is an enzyme responsible for the anti-oxid...

Many causes of levothyroxine malabsorption have been described in the literature such as celiac disease, giardiasis, severe liver cirrhosis and drug interactions. A 27-year-old woman admitted to our institution with overt hypothyroidism symptoms. She had total thyroidectomy for thyroid papiller carcinoma and was using 400 μg/day levothyroxine (LT4). Her serum free thyroxine (fT4), free triiodothyronine (fT3) and thyrotropin stimulating hor...

Introduction: The non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) identifies a group of hyperinsulinemic hypoglycemic patients with unique clinical, diagnostic, surgical, and pathologic features. A selective arterial calcium stimulation test (SACST) with hepatic venous sampling can be performed to distinguish between a focal abnormality (insulinoma) and a diffuse process (islet-cell hypertrophy/nesidioblastosis). In patients with insulinoma, the response is positi...

Aims: Glomerular and tubulointerstitial damage plays a role in renal function failure in diabetic patients. While both serum and urine levels of neutrophil gelatinase-associated lipocalin (NGAL) show significantly increased levels in acute renal pathologies, the NGAL increase in active phase indicates a reversible condition in chronic cases. In this study, we determined if urinary excretion of NGAL can be used as an early indicator of diabetic nephropathy, which causes chronic...

Background: Isotretinoin has been used for many years to treat moderate or severe nodulocystic acne, disorders of sebaceous gland and keratinization and in the prevention of skin cancer. Certain types of retinoids may cause abnormalities in serum thyroid function tests by suppressing thyroid stimulating hormone (TSH). However, it is uncertain whether systemic isotretinoin has any effect on thyroid functions.Case: 18 years old woman has admitted to our ho...

Background: After the diagnosis of corticotropin (ACTH) dependent Cushing’s syndrome established, its cause must be determined. Cushing’s disease (CD) is caused by corticotropin (ACTH) secreting adenomas and it accounts for roughly 75-80% of all endogenous Cushing’s syndrome. These adenomas are almost always benign. Renal cell carcinoma (RCC) is the most seen kidney cancer. In this case report, a presentation of a patient who was diagnosed with concurrent CD and...

Background: Acromegaly is a rare endocrine disorder characterized by sustained hypersecretion of growth hormone (GH) with concomitant elevation of insulin-like growth factor I (IGF-I) associated with acral enlargement, sleep apnea, cardiovascular and metabolic disorders. Its annual incidence is approximately six per million people. The most common cause of acromegaly is a somatotroph (growth hormone-secreting) adenoma of the anterior pituitary.Methods: A...

Background: Although hyperthyroidism has many treatment options, hyperthyroidism is difficult to control in some patients. Hyperthyroidism has three main treatment options: antithyroid drugs, radioactive iodine therapy and surgical treatment. However, in some cases none of these treatments can be used. However, there are some patients who failed to respond to radioactive iodine therapy, patients who choose not to receive any one of the options, and others who are poor surgical...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma and is derived from thyroid follicular cells which originate from the endodermal origin. In contrast, medullary thyroid carcinoma (MTC) is rare and originates from the parafollicular C-cells, which are commonly thought to be derived from the ectodermal neural crest. Co-incidence of the two condition on the same patient is so rare. We describe a case of concurrent MTC and PTC occurring in the s...